Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE)
Informing through evidence, transforming through engagement.
The Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) is a nationally endorsed guideline process that targets primary health care practitioners.
C-CHANGE is a composite of Eleven of Canada’s cardiovascular-focused clinical practice guidelines chosen to meet primary care needs, including managing patients with multiple co-morbidities. These guidelines have been part of Canada’s robust and successful cardiovascular guideline efforts since 2011​.
LEARN MORE ABOUT C-CHANGE.
CHEP+
The implementation and dissemination arm of
C-CHANGE
The mission of CHEP+ is to improve health care quality and patient safety. This is done with enhanced continuing professional development (CPD) programs, and health consumer education.
LEARN MORE ABOUT CHEP+
BRAIN-HEART INTERCONNECTOME (BHI) and C-CHANGE
Brain and heart conditions are leading causes of disease and death in Canada, with a devastating impact on patients and their families. They are also deeply interconnected, in ways that are now beginning to be understood.
The Brain-Heart Interconnectome (BHI) is a ground-breaking interdisciplinary research program aimed at accelerating prevention, detection, treatment and care of brain-heart disorders, supported by a $109 million grant from the Canada First Research Excellence Fund (CFREF).
>> Learn more about the BRAIN-HEART INTERCONNECTOME
C-CHANGE has developed the first ever Brain-Heart Clinical Practice Guideline, March 2026 in the Canadian Medical Association Journal (CMAJ): "Management of brain–heart multimorbidity: a clinical practice guideline".
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Management of brain–heart multimorbidity: a clinical practice guideline
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Jodi D. Edwards, Zhe Li, Philip McFarlane, Doreen M. Rabi, Jeremy Gilbert, Harpreet S. Bajaj, Bradley J. MacIntosh, Jesse Bittman, Ross D. Feldman, George Dresser, Kristin Terenzi, Rick Swartz, Jonathan Gabor, Glen J. Pearson, Peter Selby, Sean Wharton, Darren E.R. Warburton, Smita Pakhalé, Rima Styra, Brian Baker, Karen Tu, Michael Hawkins, James A. Stone, Tracy Vaillancourt, Stephanie Poon, Sean A. Virani, Rahul Jain, Peter Hayward Jones, Roopinder K. Sandhu, Aravind Ganesh, Jason G. Andrade, Sol Stern, Jeffrey Habert, Léna Rivard, Paul Roumeliotis, Jacob A. Udell, Tavis Campbell, Simon L. Bacon, Luc Trudeau, Karim Keshavjee, Thuy Pham, Gemma Cheng, Krystina B. Lewis, Marion Maar, Dawn Stacey, Brian Oldenburg, Abida R. Dhukai, Sachin V. Pasricha, Diana Sherifali, Megan Racey, Diane Hua-Stewart, Christopher A. Gravel, Meghan Lewis, Sumali Mehta, Michael D. Hill, Nazia Haider, Patrice Lindsay, Peter Liu and Sheldon W. Tobe
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Read the Guideline:
CMAJ March 30, 2026 198 (12) E425-E439; DOI: https://doi.org/10.1503/cmaj.251137
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Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update
Rahul Jain, James A. Stone, Gina Agarwal, Jason G. Andrade, Simon L. Bacon, Harpreet S. Bajaj, Brian Baker, Gemma Cheng, David Dannenbaum, Mark Gelfer, Jeffrey Habert, John Hickey, Karim Keshavjee, Darlene Kitty, Patrice Lindsay, Mary R. L’Abbé, David C.W. Lau, Laurent Macle, Michael McDonald, Kara Nerenberg, Glen J. Pearson, Thuy Pham, Alexandre Y. Poppe, Doreen M. Rabi, Diana Sherifali, Peter Selby, Eric Smith, Sol Stern, George Thanassoulis, Kristin Terenzi, Karen Tu, Jacob Udell, Sean A. Virani, Richard A. Ward, Darren E.R. Warburton, Sean Wharton, Jennifer Zymantas, Diane Hua-Stewart, Peter P. Liu and Sheldon W. Tobe
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Read the Guideline:
CMAJ November 07, 2022 194 (43) E1460-E1480;
